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10.1016/j.diabres.2021.109118 32 PapamargaritisD.Al-NajimW.LimJ.CraneJ.BodicoatD

The peptide is metabolized by standard peptidase activity but shows unusual resistance to gastric acid degradation, with stability documented in pH as low as 1.5 for over 24 hours

First, we emulated the two cardiovascular outcome trials SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) using the RCT-DUPLICATE approach to benchmark findings and inform the study design and analytic approach for expanded questions

GLP-1 drugs are usually optional when following a healthy lifestyle program, but initially can be useful along with other drugs that maybe warranted to help correct / control abnormalities, MD determined