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Studies report nausea, flushing, appetite suppression, and sympathetic effects in some experimental models

This slowed digestion is how the medication creates satiety signals and reduces hunger, but it can also mean nutrients spend more time in the stomach before absorption begins

3 Evolution of GLP-1-based therapeutics 3.1 First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig

doi:10.1056/NEJMoa1901118 2024 The Author(s)