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Landmark trials such as EMPA-REG OUTCOME, LEADER, SELECT, SURPASS-CVOT, and VESALIUS-CV have not only redefined therapeutic priorities but have also catalyzed a conceptual shift from glucocentric management to an integrated cardiorenal metabolic (CRM) framework

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As regulation changes and pharmaceutical companies move deeper into the space, access may shift but education and consumer awareness are pushing the peptide movement forward

They reveal actionable targets spanning signaling, metabolic, and vesicular recycling pathways, offering a robust foundation for designing novel drug combinations