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in multiple mouse models of obesity, this led to a decrease in body weight and the correction of dyslipidemia [141]

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(Growth Hormone and IGF Research, 2003) reviewed peptide therapy approaches targeting the somatotropic axis and documented measurable shifts in body composition in subjects with growth hormone deficiency, including reductions in adipose tissue, improvements in lean muscle mass, positive changes in bone mineral parameters, and favorable metabolic marker changes

1,2,6 Skin hyperpigmentation, glossitis, and infertility have also been reported