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The critical gap is the absence of controlled studies testing the two together, so any conclusion about combined effects remains speculative as of 2026

Because B12 is primarily found in animal products (meat, fish, dairy, eggs), people following vegetarian or vegan diets may be at higher risk of deficiency

Importantly, Researchers characterized orally active SLU-PP-915, analyzed SLU-PP-332 metabolites by LC-HRMS/MS, and published structureactivity research on the SLU-PP-332 scaffold

In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop