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Patients using insulin or insulin secretagogues (such as sulfonylureas) face increased hypoglycemia risk with tirzepatide dose increases

It's generally advised against in individuals with a personal or family history of medullary thyroid carcinoma or in those with Multiple Endocrine Neoplasia syndrome type 2

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On a TB syringe marked in tenths, "25" means 2.5 ml, which is 250 units