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However, because not all G6PD-deficient newborns have NNJ ( Table 18-6 ), it is likely that genetic or environmental factors (or both) are involved in addition to G6PD deficiency and that the same factors that are more extreme can also make the NNJ more severe

In the past twenty years, and mainly by repurposing drugs use, molecules have been identified but to date, clinical trials display moderated efficiency

Tubuloglomerular feedback An adaptive mechanism that links the rate of glomerular filtration to the concentration of salt in the tubule fluid, which is sensed by specialized cells in the macula densa

Combining therapies should always be done under medical guidance to ensure doses are appropriate and spacing between treatments is safe