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22 While previous smaller studies had not found any consistent evidence of an increased risk of the first onset of major depression during the perimenopause 6 , in a recent large, mostly cross-sectional, study including over 120 thousand UK Biobank participants, the incidence of first onset major depressive disorder was 30% higher (95% CI 16-45%) in the four years surrounding the final menstrual period than ten to six years before

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Of medical importance, the discovery of the DPP-4 protease resistant exendin-4 from venom of Heloderma suspectum paved the way for the successful development of GLP-1 analogues as important treatments for insulin resistant type 2 diabetics

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