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In order to maintain a steady supply of glucose, glucagon strongly stimulates glycogenolysis and suppresses glycogenesis in the liver [28, 29]

USA 94, 1967 (1997)

The takeaway: berberine has a legitimate, research-backed role in supporting healthy blood sugar for people looking for a natural option, but it is not a diabetes treatment and should never replace prescribed medication

Ellagic acid inhibits key epigenetic enzymes, EZH2 and PRMT5:MEP50, with strong binding affinities, reducing their catalytic products, H3K27me3 and H4R3me2s [74]