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Specifically, 2.12 mM GDC increased calcitonin permeability in Caco-2 monolayers by 10.66-fold and decreased TEER by 4.57-fold (52), whilst 0.5 mM GDC increased [ 14 C]-mannitol apparent permeability (Papp) by 3-fold and transiently decreased TEER by 2.5-fold, without reducing cell viability (MTS, CellTox Green assay, Caspase 3/7) (44)

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