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In addition, -asarone protects hippocampal neurons from chronic unpredictable mild stress-induced cell death by down-regulating mitogen-activated protein kinase phosphatase-1 (MKP-1), thereby activating extracellular signal-regulated kinase 1/2 (ERK1/2 or mitogen-activated protein kinase) or CREB signalling cascade phosphorylation, thereby up-regulating brain-derived neurotrophic factor (BDNF) expression