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Congress and the FDA responded with provisions in the FDA Safety and Innovation Act requiring innovators to provide REMS-compliant access to reference product samples for bioequivalence testing [23]

If you're considering stopping treatment or switching medications, discussing the timeline with your prescriber helps set realistic expectations about when appetite and metabolism will normalize

When to seek medical advice: Persistent injection site reactions lasting more than one week Signs of infection (increasing warmth, spreading redness, purulent discharge, fever) Severe pain or swelling at the injection site Signs of severe allergic reaction (widespread rash, difficulty breathing, facial swelling) seek urgent medical attention or call 999 Unexplained lumps or significant changes in subcutaneous tissue Patients experiencing recurrent or troublesome injection site problems should consult their GP or diabetes specialist nurse, who may recommend alternative injection sites, review technique, or consider whether the reactions represent a hypersensitivity to the medication