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If HbA1C levels are 9.0% or higher, initial treatment may comprise two or three medications at maximal dosages

Karkkainen J, Laitinen T, Markowicz-Piasecka M, Montaser A, Lehtonen M, Rautio J, Gynther M, Poso A, Huttunen KM

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

however, there are important caveats: - Injection-site reactions: As with any injectable peptide, mild redness, swelling, or irritation at the injection site appear to be the most commonly reported side effects