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Patients with PCOS demonstrate dysregulated expression of steroid hormone receptor and homeobox A10 (HOXA10), which play crucial roles in the process of embryo implantation within the endometrium

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The heavy GCLC is both the catalytic unit and the regulatory site of GSH feedback inhibition, while the light subunit regulates the activity of the holo-enzyme by modulating the affinity of the two regulatory sites of GCLC, that for glutamate and that for glutathione thereby making the enzyme more efficient and less sensitive to feedback inhibition