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Louwagie tells Endocrine News that that he and his co-authors would want clinicians to keep this potential side effect in mind for all patients presenting with signs of ketoacidosis while on tirzepatide

If you dont eat for long periods, blood sugar tends to drop

If GLP-1s slow absorption, they could be weakening that rapid feedback loop, not by dulling desire directly, but by changing the tempo of intoxication itself