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Alizadeh SR, Savadkouhi N, Ebrahimzadeh MA (2023) Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives
It helps with signaling and cell growth
That could still supply the building blocks for endogenous glutathione synthesis within the cells but it doesnt address the degradation of the enzymatic function
For instance, the GSH/GPX4 axis serves as a barrier to obstruct ferroptosis, while cys is the inhibitory amino acid in the synthesis of GSH and blockade of cys import via SLC7A11 triggering ferroptosis by decreasing GSH levels (Sun et al., 2018)
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