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Pregnancy Tell your healthcare provider if you are pregnant or plan to become pregnant Tell your healthcare provider if you become pregnant while using Zepbound Limited data on Zepbound use in pregnant women are available to inform on drug-associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes Based on animal reproduction studies, there may be risks to the fetus from exposure to Zepbound Use only if potential benefit justifies the potential risk to the fetus Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy

Peptides containing certain amino acid residues prove particularly susceptible to oxidative degradation

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A phase Ib study showed that R1507 is well tolerated when added to six standard chemotherapy regiments in patients with various solid tumors, including BrCa [128]