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The molecular basis of the pharmacological resistance are still poorly understood, and several potential molecular mechanisms have been proposed, including defective expression or genetic alterations of DRD2 and SSTRs, or an impaired signal transduction

Through formulation of water-soluble antioxidants NAC and NACET in a hypotonic, gel-forming vehicle, we demonstrated the potential for protection of retina structure and function in rodents

Furthermore, GSH supplementation has been shown to protect HIV patients from a variety of opportunistic diseases by (i) mitigating oxidative stress and chronic inflammation in HIV-associated neurodegenerative diseases, (ii) improving Th17 responses in HIV patients who have impaired gut mucosal defenses, and (iii) restoring Th1 responses to protect patients from TB coinfection

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