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Signal was defined when the EBGM05 metric, a lower one-sided 95% confidence limit of the EBGM 2.0 [Reference Sakaeda, Tamon, Kadoyama and Okuno20] or the lower limits of the 95% confidence intervals (95% CIs) of ROR exceeded 1 in at least three reports [Reference Zhai, Ye, Hu, Xu, Guo and Lin21]

Overuse can lead to dryness, so keep the routine balanced

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Nausea was reported among patients receiving both VK2735 (43%) and placebo (20%)