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Docking substrates into the active site of the mutant Asn240Lys suffered from steric and entropic problems as Lys at position 240 oscillates (as evidenced by docking showing a wide range of different Lys240 positions), thereby obstructing access to the active site
Acetylcysteine is used as a mucolytic agent in the adjunctive treatment of patients with abnormal, viscid, or inspissated mucous secretions in such conditions as acute and chronic bronchopulmonary disorders (e.g., pneumonia, bronchitis, emphysema, tracheobronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis, primary amyloidosis of the lung)
Monotherapy-versus-combination asymmetry
A study specifically measuring ALCARs safety for elderly patients also found that it can be taken without significant side effects (17)
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