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The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs

were also found to modulate oxidative stress, antioxidative activities, and liver function to protect against APAP-induced hepatotoxicity in rats with higher potentials in the seed extract for protection of the liver (Lakshmi et al., 2018)

Table 2 Frequency of patients in each timepoint assessed for each variable

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