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Metformin is often used when someone has insulin resistance

Several mechanisms have been proposed to explain the cytotoxic properties of ascorbate as a co-chemotherapy agent (Schoenfeld et al

Subclinical magnesium insufficiency is widespread and under recognized, largely due to the current state of the Western food system and mineral depletion in the soil.* [1] Circulating levels of magnesium in the blood are not always an accurate representation of total magnesium levels, as magnesium will be pulled from other bone and muscle tissues when circulating levels are low.* [3] This further elucidates the importance of regular magnesium supplementation.* Those most likely to have insufficient magnesium levels are those who exercise intensely (magnesium can be lost in sweat), older adults (intestinal absorption is reduced with age, especially in postmenopausal women), those with specific gut issues (and subsequent malabsorption issues, at any age), those with insulin or blood-sugar balance concerns, those on a gluten-free or otherwise restrictive diet, and those who regularly drink alcohol.* [1] Why Magnesium Glycinate

Mol Psychiatry 18:595606