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Chen Y, Yuan M, Mohanty A, Yam JK, Liu Y, Chua SL, Nielsen TE, Tolker-Nielsen T, Givskov M, Cao B, Yang L

It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

The double-blind clinical trial of 1961 adults with overweight or obesity without diabetes found that the average weight loss after 68 weeks was about 15 percent of body weight for those given semaglutide versus only about 2.5 percent for those taking the placebo

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