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Selective protection of normal proliferating cells against the toxic effects of chemotherapeutic agents

What works initially in terms of performance and recovery may change as the body adapts

Survodutide (BI 456906), developed by Boehringer Ingelheim and Zealand Pharma, has completed Phase 2 trials for both obesity (up to 18.7% weight loss at 46 weeks) and MASH (62% MASH resolution), earning FDA Breakthrough Therapy Designation for MASH

Using Kaede photoconvertible mice, experiments demonstrated that CD8+ effector T cells that enter and stay in the tumor develop an exhausted phenotype within 72 hours, whereas non-effector TCF1+ stem-like CD8+ T cells are continuously trafficked between the tumor and the TDLNs (47)