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Microarray and transcriptomic analyses have shown that GHK-Cu modulates the expression of hundreds of genes in human fibroblasts, with research interest in understanding which regulatory networks are engaged

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This process relies on KLF1 (Krueppel-like factor 1), FOXO3 (forkhead box O3), and E2F2 transcription factors, chromatin condensation-regulating caspase-3, DNA methylation-regulating Tet family proteins, Asxl1, cytoskeleton-regulating Rho GTPases, and p38 MAPK signaling [51, 52]

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