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These nutrient-based secretagogues include: Dietary lipids, especially triacylglycerol which is the primary fat found in foods Dietary carbohydrates, particularly those yielding glucose Short chain fatty acids (SCFAs) produced from fiber fermentation by gut microbes The high density of L-cells in the large intestine makes it a prime target for SCFA-mediated GLP-1 secretion

Recently, Merck and Hansoh Pharmaceutical announced that they have signed a global exclusive licensing agreement for HS-10535, an oral small molecule GLP-1 receptor agonist currently in preclinical research

To view a copy of this licence, visit About this article Cite this article Su, Q.J., Ashenhurst, J.R., Xu, W

Informing patients on potential side effects, gradual dose escalation, and contraindications is essential to ensure safety and adherence