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Patients with swelling should be assessed for cardiac, renal, or hepatic causes of oedema, particularly if swelling is persistent, unilateral, or accompanied by breathlessness or significant weight gain

In a recent RCT, ertugliflozin improved left ventricular global longitudinal strain in people with type 2 diabetes mellitus and pre-HF, effects associated with increased ACE2 and angiotensin (17) levels, suggesting a potential underlying mechanisms [91]

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