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Genetic Findings of GSH GS deficiency is a rare disorder of glutathione (GSH) metabolism manifested in children by severe metabolic acidosis with high urinary level of 5-oxoproline (pyroglutamic acid), hemolytic anemia, and neurological events

10.1073/pnas.74.3.931 Proc

The platform uses hydrophilic interaction liquid chromatography with positive/negative ion switching to analyze 258 metabolites (289 Q1/Q3 transitions) from a single 15-min targeted liquid chromatographytandem mass spectrometry (LCMS/MS) acquisition with a 3-ms dwell time and a 1.55-s duty cycle time (Yuan et al