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Given its ample range of functions in the nervous system, it is not surprising to find significant alterations in glutathione levels and/or glutathione-related enzymes during brain aging and in several neurological conditions including Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), schizophrenia, and chronic fatigue syndrome (CFS)
10.1158/1535-7163.MCT-11-0754 12 ChenL.XuL.WangG
Potential therapeutic targets are low-grade systemic inflammation, oxidative stress, NO signaling, RAAS signaling, ECM remodeling, calcification, VSMCs, and cellular senescence
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