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Consumers should consult qualified healthcare providers before starting any new dietary supplement, particularly if they have existing health conditions, take medications, are pregnant or nursing, or are considering significant changes to their health regimen

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Regulation is carried out by binding Nrf2 to a specific DNA sequence known as the antioxidant response element (ARE) found in the promoter regions of genes that encode detoxification enzymes such as NADPH quinone oxidoreductase 1 (NQO1), haem oxygenase 1 (HO-1) and glutathione peroxidase 1 (GPx1), among others [55]