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Science 2002;297:353-6
Hormones and all essential amino acids have substrate-specific transporters, although cationic amino acids (lysine and arginine) or large neutral ones (tryptophan, tyrosine) share a transporter system (cationic amino acid transporters 1 and 3 (CAT-1/3)
These effects are hypothesized to reduce inflammation and improve structural recovery, but they remain confined to controlled animal experiments
Systemic medical conditions that compromise tendon integrity, such as connective tissue disorders, chronic renal failure, systemic lupus erythematosus or rheumatoid arthritis, as well as corticosteroid use increase the risk of tendon rupture
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