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GLP-1 receptors are found in the hypothalamus (appetite regulation), hippocampus (memory formation), brainstem (nausea responses), ventral tegmental area and nucleus accumbens (reward circuits), amygdala (emotional processing), prefrontal cortex (executive function), and substantia nigra (motor control)

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Seek medical advice if you experience: Persistent or severe nausea and vomiting that prevents adequate fluid or food intake, or lasts beyond the first few weeks of treatment Signs of dehydration : extreme thirst, dizziness, reduced urine output, dark concentrated urine, confusion, or rapid heartbeat Severe or persistent abdominal pain , particularly if accompanied by vomitingthis may indicate pancreatitis, a rare but serious adverse effect

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