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International journal of nanomedicine, 17, 48294842

Abbreviations ALP: alkaline phosphatase ALT: alanine aminotransferase AST: aspartate aminotransferase CKD: chronic kidney disease GGT: gamma glutamyl transpeptidase HGF: hepatocyte growth factor HPP: hypophosphatasia NSHA: nonspherocytic hemolytic anemia PLP: pyridoxal 5-phosphate TNSALP: tissue-nonspecific alkaline phosphatase Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis Research is gratefully acknowledged

Multidrug Resistance-associated Protein 1 (MRP1) and MRP2, of the ABC (ATP-Binding Cassette)-type subfamily C transporters, transport oxidized glutathione and glutathione S-conjugates when expressed in yeast 58,59 and might be involved in their transport from the cytosol into the vacuole in plants

One of the key active ingredients is apigenin