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In the STEP 1 (Semaglutide Treatment Effect in People with obesity) extension study, participants regained about twothirds of the weight they had lost with semaglutide within one year, accompanied by declines in cardiometabolic health [140]

doi:10.1111/dom.14725

Notably, an increase in the permeability of these new blood vessels promotes infiltration of various inflammatory factors into the cartilage, which exacerbates cartilage degeneration and OA severity (3,4)