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It works by binding to the ghrelin receptor in the hypothalamus and pituitary gland, triggering an increase in growth hormone levels

Participants Adults (18 years old) with 1 or more self-reported unsuccessful dietary weight loss efforts and a body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 30 or greater or 27 or greater with 1 or more weight-related comorbidities (hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease) were eligible (eAppendix 1 in Supplement 3)

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doi: 10.1007/s11883-022-01074-y 198 SayedAShazlyOSlipczukLKrittanawongCBalochFViraniSS