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But that benefit may be due to the patients themselves: those who are healthier, wealthier and with better access to care

Nutrients endowed with anti-inflammatory properties, including vitamins (such as vitamin C and vitamin E), quercetin, resveratrol, curcumin, and epigallocatechin-3-gallate (EGCG), hold the potential to diminish the lesions associated with endometriosis and thus exhibit latent therapeutic implications

Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties.3 Hence, through the histopathological examination of melanocyte activity, location of melanin pigment deposition, and response after therapy, we can determine the effects of glutathione on skin color.6,9 However, Arjinpathana and Asawanonda1 reported many contradictory results regarding the efficacy and safety of glutathione as a skin-lightening agent

Ethics declarations Conflict of Interest Stephano Cedirian, Monia Donati, Luca Rapparini, Francesca Pampaloni, Michelangelo La Placa, Rossella Sgarzani, Luca Negosanti, Emanuel Raschi and Michela Starace is an Editorial Board member of Dermatology and Therapy