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However, exenatide has no effect on 3xTg-AD mice, suggesting that its benefits are model-specific [77]

Effects of Exenatide and Liraglutide on Heart Rate, Blood Pressure and Body Weight: Systematic Review and Meta-Analysis

Lilly expects to launch orforglipron for obesity in the United States in the second quarter of 2026 and in most international markets during 2027

Theyve also been linked, though rarely, with more severe side effects like They also have a notoriously high discontinuation rate: between 50-75% of people who start them stop using them within a year