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Contact your GP if you experience: Unintentional weight loss or gain exceeding 5% of your body weight over 13 months Rapid weight changes that concern you, regardless of the amount Weight changes accompanied by other symptoms such as fatigue, persistent vomiting, changes in bowel habits, night sweats, or unexplained pain Difficulty maintaining a healthy weight despite lifestyle modifications Your doctor can investigate whether the weight change relates to fluoxetine, an underlying medical condition (such as thyroid dysfunction), or other factors requiring attention