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Barking Essex 1987 287, 117557

For instance, a multicenter, placebo-controlled RCT could enroll several hundred heart failure patients on optimal therapy, randomizing them to add-on therapy with a purified TCM metabolite (at a standardized dose) versus placebo for 1 year

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Apart from TRPC channels, a role for ionotropic glutamate receptors for Ca 2+ entry has been suggested: NMDA receptors permeable to Ca 2+ accomplish Ca 2+ homeostasis [102, 103], and also AMPA receptors may be relevant as pharmacological AMPA receptor antagonism blunts Ca 2+ entry into erythrocytes in response to Cl - removal [104]