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The favorable community experience provides context but cannot definitively answer the cancer safety question that only proper long-term human studies could address

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reported that genetic deletion or pharmacological inhibition of DHODH did not substantially alter ferroptosis sensitivity across multiple cellular models, suggesting that its protective role may be overstated or highly context dependent 92

We have stated that we believe there is a national market for these items and there is not significant geographic variation in those costs, and as such we assign a value of 1.00 for this component for each locality, consistent with the national average