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Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1

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Food and Drug Administration (FDA) for obesity management, have shown efficacy not only in weight reduction but also in improving metabolic 10,11,12,13,14,15 and cardiovascular outcomes 16

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