Similarly to asthma, mast cells, Th2 cells, basophils, and epithelial cells synthesize and release cytokines and chemokines (IL-3, IL-4, IL-5, IL-10, IL-13, GM-CSF, and RANTES), which are responsible for sustaining allergic inflammation and the associated oxidative/nitrosative stress (116118)
The body primarily relies on producing its own
Shown is the phagocytosis by THP-1 cells (panel A) of ring-infected and non-infected GR-deficient RBCs from the index patient, brother (individual 2) and sister (individual 3) of the index patient, and from normal GR-sufficient controls
Separately, the pooled RRs were 0.78 (95% CI=0.28-2.14, P=0.62), 0.99 (95% CI=0.28-3.49, P=0.99), 0.33 (95% CI=0.44-2.99, P=0.32), 1.59 (95% CI=0.29-8.59, P=0.19), 1.59 (95% CI=0.29-8.59, P=0.59) and 1.64 (95% CI=0.23-11.74, P=0.62)