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Arch Intern Med

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At the top of the figure, folate is reduced to dihydrofolate and then further reduced to tetrahydrofolate, which enters a circular pathway

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5,10-Methylenetetrahydrofolate is required for the synthesis of nucleic acids

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Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

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