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Biomedicines 2021

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Higher doses are linked to more GI side effects, especially nausea, while gradual titration lets the body adapt, and randomized studies of once-weekly semaglutide and tirzepatide found that increasing the dose every 4 weeks, rather than starting high, improved tolerability while preserving efficacy

Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis