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What could possibly cause it and what can I do to reduce it

Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

References Glutathione is a low-molecular-weight thiol tripeptide vital in maintaining intracellular redox balance