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This activation is accompanied by vital methylation reactions that allow the synthesis of creatine and phosphatidylcholine and the methylation of DNA, RNA, and a large number of neuromediators

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Loading Phase Rationale : This need for sustained, systemic saturation is why TB-500 protocols traditionally include an initial loading phase of higher weekly doses (e.g., 5 to 10 mg total over the first 4-6 weeks) [3]

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