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Preclinical models report signals relevant to tendon/ligament, muscle, and dermal recovery, with exploratory markers tied to microvascular support and extracellular matrix dynamics

However, when the energy charge is low, pyruvate is preferentially oxidized to CO 2 and H 2 O through the activities of the pyruvate dehydrogenase complex (PDHc) and the enzymes of the TCA cycle, with generation of approximately 15 moles of ATP per mole of pyruvate