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Nissen expects tirzepatide to soon join the pure GLP-1 RAs with an FDA-approved indication for weight loss in addition to diabetes, although it may meet the same payer reluctance around reimbursement for weight loss that the pure GLP-1 RAs have

The net effect on potassium is unpredictable, which is exactly the wrong environment for a drug that already shifts potassium homeostasis

Abnormal blood vessels in the esophagus, stomach, or duodenum Conditions such as esophageal varices or gastric varices, which are enlarged and fragile blood vessels, can cause bleeding and result in black, tarry stools

Patients experiencing GLP-1 digestion issues may notice bloating, infrequent bowel movements, or abdominal discomfort-especially during the first few weeks or when doses increase