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Furthermore, a significant increase in the protein expression of pS396-tau, pT231-tau, and pS202/205-tau and a decreased number of neurons in the hippocampus and prefrontal cortex were observed

By synchronizing the body's physiology with the photoperiod, melatonin helps regulate circadian rhythms.14 Certain pharmacological agents can influence pineal gland activity and alter plasma melatonin concentrations

Tyrosinase activity can also increase the risk of developing hyperpigmentation of the cheeks, forehead, and upper lip, a condition known as melasma, which may remain after pregnancy