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(2) Scientists such as Mun et al have also observed that when Melanotan I activates MC1R, cAMP is produced, and it activates microphthalmia transcription factor (MITF) expression, which induces the expression of enzymes for eumelanin production

Molecules 27 (15), 4888

Clinical protocols in the UK will likely emphasize a start low, go slow approach, utilizing doses as low as 1 mg or 2 mg for initial titration to minimize GI distress